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Evaluation of mifepristone effects on alcohol-seeking and

This is an 8-week, randomized, double-blind, placebo-controlled, 2 arm, parallel groups, study of 1-week of treatment with mifepristone (0, 1200 mg/d) given in conjunction with 8 weeks of manual-guided counseling, and a follow-up visit at Week 12. Full Title of Study: Glucocorticoid Antagonist Treatment of Alcohol Use Disorder Study Typ A single dose of mifepristone given at the time of alcohol withdrawal significantly reduced the memory deficits in both tests. NeuN staining showed no evidence of neuronal loss in either prefrontal cortex or hippocampus after withdrawal from chronic alcohol treatment

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Korlym (mifepristone) drug interactions. There are 572 drug interactions with Korlym (mifepristone) Korlym (mifepristone) disease interactions. There are 6 disease interactions with Korlym (mifepristone) which include: organ transplant; vaginal bleeding; cardiovascular disease; hepatic impairment; long QT; renal impairmen sir plz help me today i take mifprestone tablets now what i have to do for medical abortio Mifepristone is a synthetic steroid used for the termination of an early pregnancy. It is also used for the management of high blood sugar levels in people with people with high level of cortisol for a prolonged duration (Cushing's syndrome). Buy Mifepristone Online. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions. Mifeprex and alcohol interactions: It is recommended that women should not drink alcohol even moderate drinking while consuming Mifeprex. During this time the medical community terms moderate drinking of alcohol shouldn't exceed more than two pegs per day and more than 14 pegs per week Our results corroborate and extend previous studies indicating that mifepristone decreases both alcohol drinking under limited-access conditions and the severity of alcohol withdrawal . Because mifepristone potently inhibits both GR and progesterone receptor function, we tested the effect of a selective GR antagonist on alcohol drinking

Mifepristone for the Prevention of Relapses of Alcohol

  1. ations
  2. e the potential efficacy of mifepristone, a type II glucocorticoid receptor antagonist, to prevent symptoms of depression and cognitive deficits following alcohol detoxification. Methods: This was a phase 2 therapeutic use trial. It was a double-blind randomised controlled clinical trial of mifepristone versus inactive placebo treatment
  3. Compared with placebo, mifepristone reduced alcohol-cued craving that has been shown to be predictive of relapse drinking and reduced self-reported alcohol consumption. Mifepristone, in addition to its antagonism at type II glucocorticoid receptors, has progesterone antagonist properties
  4. Mifepristone is a prescription medication used to treat high blood sugar caused by high cortisol levels in the blood in adults with Cushing's syndrome and type 2 diabetes or glucose intolerance. Mifepristone belongs to a group of drugs called cortisol receptor blockers, which block the actions of cortisol to lower blood sugar levels
  5. You should not drink any alcohol or use drugs prior to, during, and after using the medicines, as it can affect your Why do you only need 4 tablets of Misoprostol after taking Mifepristone? W hy do we also recommend taking o ne extra dose of 2 Misoprostol 3-4 hours after the first dose
  6. ation of intrauterine pregnancy through 49 days' pregnancy. Doses of 1 mg/kg or greater of mifepristone have been shown to antagonize the endometrial and myometrial effects of progesterone in women

Mifepristone, a type II glucocorticoid receptor antagonist, is under investigation as a potential pharmacotherapy for alcohol use disorder. This study examined effects of chronic administration of mifepristone on alcohol-seeking and self-administration in large nonhuman primates Importantly for the current study, Vendroluscolo et al. showed that mifepristone reduced the increase in operant responding for alcohol seen in alcohol-dependent rats, without affecting responding in rats not dependent on alcohol. In a recent clinical trial, mifepristone was administered at 600 mg daily for 1 week to alcohol-dependent individuals who continued to drink alcohol for the first 4 days of the treatment Similarly, Vendruscolo and colleagues (2012) reported that chronic mifepristone treatment via s.c. pellet (150 mg/kg for 21 days) was associated with reduced alcohol intake following intermittent alcohol vapor exposure and alcohol intake associated with long-term abstinence from exposure Treatment: Mifepristone 600-mg/day or placebo for a week Clinical Study Identifier: NCT0224370 Mifepristone comes as a tablet to take by mouth. You will take one tablet of mifepristone once on the first day. Within 24 to 48 hours after taking mifepristone, you will apply four tablets in total of another medication called misoprostol buccally (between the gum and cheek) by placing two tablets in each cheek pouch for 30 minutes, then swallowing the remaining content with water or another.

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Double-blind, placebo-controlled trial of mifepristone on cognition and depression in alcohol dependence Kim Donoghue1* , Abigail Rose2, Simon Coulton3, Rachel Coleman4, Joanna Milward1, Thomas Philips1,5, Colin Drummond1 and Hilary Little1 Abstract Background: Alcohol dependence is a significant issue contributing to disease burden From: $ 180.00. MTP Kit is a complete abortion kit that is used for early abortion in women. This abortion kit consists of two medicines, namely Mifepristone and Misoprostol prescribed to women who are in their first trimester or no more than 9 weeks pregnant. It comes in a combi pack containing 1 tablet of Mifepristone 200 mg and 4 tablets of.

Mifepristone, an antiprogestogenic steroid, sensitises the myometrium to prostaglandin-induced contractions and ripens the cervix. Indications and dose Cervical ripening before mechanical cervical dilatation for termination of pregnancy of up to 84 days gestation (under close medical supervision Mifepristone reduced, though did not prevent, the behavioral hyperexcitability seen in TO strain mice during the acute phase of alcohol withdrawal (4 hours to 8 hours after cessation of alcohol consumption) following chronic alcohol treatment via liquid diet Mifepristone (also known as RU 486) is used to cause an abortion during the early part of a pregnancy.It is used up to week 10 of pregnancy (up to 70 days after the first day of your last.

Request PDF | Evaluation of Mifepristone Effects on Alcohol-Seeking and Self-Administration in Baboons | Mifepristone, a type II glucocorticoid receptor antagonist, is under investigation as a. 1. Alcohol Clin Exp Res. 2013 Aug;37(8):1417-23. doi: 10.1111/acer.12093. Epub 2013 Mar 25. Mifepristone pretreatment reduces ethanol withdrawal severity in vivo. Sharrett-Field L(1), Butler TR, Berry JN, Reynolds AR, Prendergast MA Mifepristone has also been shown to decrease alcohol consumption and craving for alcohol in humans with AUD. The present study tested the effects of the GR modulators CORT118335, CORT122928, CORT108297, and CORT125134 on alcohol self-administration in nondependent (air-exposed) and alcohol-dependent (alcohol vapor-exposed) adult male rats

That is a form of the prescription you'll receive that contains two drugs- Mifepristone and Misoprostol. These medications will cause the same effect as a miscarriage, and you should take them in two doses. Mifepristone Mifepristone is the first pill you need to use. It is also called a progesterone receptor modulator I am 9 weeks pregnant. How to use (a kare) combipack of mifepristone 200 mg and 4 misoprostol 200 mcg tablets to avoid pregnancy . Please reply soon its urgent. I had sex on 25th october and took i.

RU-486, also known as Mifepristone is an oral medication used in combination with Misoprostol to terminate an early pregnancy in women. It is prescribed to women who are in their first trimester pregnancy or no more than 63 days pregnant. It is an anti progestational steroid that works by blocking the effects of progesterone, thereby softening the cervix and causing uterine contractions Instructions For Abortion With Mifepristone and Misoprostol. For an abortion with mifepristone and misoprostol, you will need to take one 200mg pill of mifepristone and four to eight 200mcg pills of misoprostol. You'll also want to have a painkiller on hand, like ibuprofen, to help manage pain Mifepriston remt de werking van het vrouwelijke geslachtshormoon progesteron. Dit hormoon is nodig om een zwangerschap in stand te houden. Artsen schrijven mifepriston voor om een zwangerschap af te breken als deze ongewenst of medisch niet verantwoord is, of als de baby in de baarmoeder is overleden. Artsen moeten zich daarbij houden aan de 'Wet afbreking zwangerschap' (abortuswet) The article below may contain offensive and/or incorrect content. Mifepristone, a type II glucocorticoid receptor antagonist, is under investigation as a potential pharmacotherap Mifepristone - Alcoholic Drink Alcoholism Coding Drug - Smoking - On The Reverse Side Free PNG is a 1024x1024 PNG image with a transparent background. Tagged under Mifepristone, Smoking, Drug, Addiction, Drug Dependence

mifepristone and alcohol provides you safe and FDA-Approved medicines to get rid of your unwanted pregnancy at your door with various shipping options just SMS at +1(720)305-1361 Mifepristone is an inhibitor of CYP3A4, an isoenzyme partially responsible for the metabolism of marijuana's most psychoactive compound, delta-9-tetrahydrocannabinol (Delta-9-THC). When given concurrently with mifepristone, the amount of Delta-9-THC converted to the active metabolite 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) may be. Enter your details like condition, age, gender and other preferences and we will show you a list of all relevant clinical trials

Double-blind, 12 month follow-up, placebo-controlled trial

Mifepristone Treatment of Alcohol Use Disorder: Alcohol

  1. Double-blind, placebo-controlled trial of mifepristone on cognition and depression in alcohol dependence Alcohol dependence is a significant issue contributing to disease burden. Changes in cortisol concentrations during alcohol withdrawal are associated with cognitive deficits and symptoms of depression
  2. This is an 8-week, randomized, double-blind, placebo-controlled, 3 arm, parallel groups, dose-ranging study of 1-week of treatment with mifepristone (0,
  3. controlled clinical trial of mifepristone versus inactive placebo. The trial aims to recruit 120 participants referred for an inpatient alcohol detoxification from community alcohol teams, who meet the inclusion criteria; 1) Male, 2) Aged 18 -60 inclusive, 3) alcohol dependent for 5 or more years

BACKGROUND: Studies were carried out to test the hypothesis that administration of a glucocorticoid Type II receptor antagonist, mifepristone (RU38486), just prior to withdrawal from chronic alcohol treatment, would prevent the consequences of the alcohol consumption and withdrawal in mice. MATERIALS AND METHODS: The effects of administration of a single intraperitoneal dose of mifepristone. PDF | Background: Alcohol dependence is a significant issue contributing to disease burden. Changes in cortisol concentrations during alcohol... | Find, read and cite all the research you need on.

Mifeprex (mifepristone) is a drug that blocks a hormone called progesterone that is needed for a pregnancy to continue. Mifeprex, when used together with another medicine called misoprostol, is. Abstract Background Alcohol dependence is a significant issue contributing to disease burden. Changes in cortisol concentrations during alcohol withdrawal are associated with cognitive deficits and symptoms of depression. Current treatments are only successful for a small proportion of people and do not target cognitive deficits and symptoms of depression experienced by those who are alcohol.

Joanna MILWARD | Post-Doctoral research associate | BSc

The aim of this research is to determine the potential efficacy of mifepristone, a type II glucocorticoid receptor antagonist, to prevent symptoms of depression and cognitive deficits following alcohol detoxification Alcohol has seven calories per gram rather than four calories per gram of protein or carbohydrates. So the calories in those drinks can add up quickly. Plus, when alcohol is in your system, the body's ability to burn fat slows down. If you're watching your weight, this is important to keep in mind The trial is a double-blind randomised controlled clinical trial of mifepristone versus inactive placebo. The trial aims to recruit 120 participants referred for an inpatient alcohol detoxification from community alcohol teams, who meet the inclusion criteria; 1) Male, 2) Aged 18-60 inclusive, 3) alcohol dependent for 5 or more years The latest data on Mifepristone. Analyze its clinical trials, drug applications, pubmed articles, and patent filings. Compare against other pharmaceutical assets The Cushing's syndrome therapy mifepristone can alleviate a liver condition that often develops along with Cushing's, a case study suggests. The disorder, which involves too many fat deposits in the liver, is called non-alcoholic fatty liver disease, or NAFLD. Researchers examined the case of a 49-year-old woman with Cushing's syndrome.

Effects of the Glucocorticoid Antagonist, Mifepristone, on

The goal of this study is to determine if, under stress, alcohol drinking is reduced using mifepristone Criteria:. Sponsors: Lead Sponsor: The Scripps Research Institute Collaborator: National Institute on Alcohol Abuse and Alcoholism (NIAAA) Source: The Scripps Research Institute Brief Summary: This is an 8-week, randomized, double-blind, placebo-controlled, 2 arm, parallel groups, study of 1-week of treatment with mifepristone (0, 1200 mg/d) given in conjunction with 8 weeks of manual-guided counseling.

Mifepristone and Misoprostol kit online known as the medical termination of pregnancy (MTP) kit contains two different kinds of drugs. · Consumption of alcohol should not be done while on abortion pills. · Breastfeeding is a risk of toxicity to the baby while the mother has been on abortion pills. Therefore, it is a complete contraindication Problems with the stomach and intestine may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, smoke, or drink large amounts of alcohol while taking diclofenac and misoprostol One dose of Mifepristone (200 mg) Four doses of Misoprostol (200 mcg) Dosage Form: Mifepristone medicine is taken orally. Misoprostol medicines can be taken buccally/vaginally. Description. The Medical Termination of Pregnancy Kit - MTP Kit consists of 1 pill of Mifepristone and 4 pills of Misoprostol. The Kit is used for ending an unplanned. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. Journal Article In: PLoS Biol, 17 (4), pp. e2006421, 2019 , ISSN: 1545-7885 (Electronic); 1544-9173 (Linking) DESCRIPTION. MIFEPREX tablets each contain 200 mg of mifepristone, a synthetic steroid with antiprogestational effects. The tablets are light yellow in color, cylindrical, and bi-convex, and are intended for oral administration only. The tablets include the inactive ingredients colloidal silica anhydrous, corn starch, povidone, microcrystalline cellulose, and magnesium stearate

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MIFEPRISTONE AND MISOPROSTOL TABLETS AVAILABLE IN QATAR DOHA ABORTION PILLS FOR SALE IN QATAR DOHA You may also receive antibiotics to prevent infection and a medication to help minimize the bleeding; avoid alcohol, as it can increase bleeding. Prior to the abortion, your blood may have been drawn to check for anemia and the Rh factor.. Scientists have discovered a way to produce eggs from scratch, in mini ovaries grown in tubes, opening up new avenues for the field of reproductive medicine and fertility. The researchers, led by Katsuhiko Hayashi of Kyushu University, Japan, created of a mouse ovary-like tissue, called an ovarioid.. They developed the ovarioid with a.

Mifepristone also attenuates other behavioral effects of alcohol that might contribute to compulsive alcohol drinking. For example, repeated restraint stress produces a sensitization of alcohol's activating (i.e., locomotor) effects in mice, and the administration of mifepristone attenuates this effect ( Roberts, Lessov, & Phillips, 1995 ) Mifepristone for the Prevention of Relapses of Alcohol Drinking - clinical trial in United States of America. Popular articles UEFA Euro 2020 - The 2020 UEFA European Football Championship , commonly referred to as UEFA Euro 2020 or simply Euro 2020 , is scheduled to be the 16th UEFA European Championship, the quadrennial international me.. Dive into the research topics of 'Evaluation of mifepristone effects on alcohol-seeking and self-administration in baboons'. Together they form a unique fingerprint. Sort by Weight Alphabetically Medicine & Life Sciences. Mifepristone 100%. Papio 93%. Self Administration 91%. Alcohols 57%. Reinforcement Schedule 57%. Pharmacokinetics 12. alcohol SA baseline was reached, we tested the effect of the GR antagonists mifepristone (0.0, 10, 30 and 60 mg/kg; i.p.) and CORT113176 (0.0, 10, 30 and 60 mg/kg) on alcohol SA. To evaluate whether the effects of the two compounds were specific for alcohol, the two drugs were tested on a similar saccharin SA regimen Alcohol is a very popular choice since it increases GABA activity and in the short run that lowers cortisol levels. GABA agonists are used clinically to treat he hypercortisolemia of Cushing syndrome. This human study showed that giving alcoholics a dose of RU486 (mifepristone) strongly decreased the alcohol seeking/craving

Can you consume alcohol or vape marijuana while taking Mifepristone and/or Mifeprex? What would happen?Bonus Question: Why is it that after taking the abortion pills, nothing can be inserted into the vagina (including tampons) How to Abort at home with Pills (misoprostol, cytotec)? The best and safest way a woman can do an abortion herself until the 12th week of pregnancy is with the use of two medicines called Mifepristone (also known as the abortion pill, RU 486, Mifegyn, Mifeprex, Zacafemyl), and Misoprostol (also known as Cytotec, Arthrotec, Oxaprost, Cyprostol, Mibetec, Prostokos or Misotrol) And then we have an alcohol, like that. So this molecule, since it has such a similar structure to vanillin, also has a nice vanilla smell. It's very pleasant. So this is a very good undergraduate organic chemistry lab to do. And let's classify the type of alcohol we got as either primary, secondary, or tertiary Questions and Answers about Abortion Pills. Whether you are a person in need of an abortion, a journalist or just curious about our service, here are some frequently asked questions. Every question has a simple answer and a more in-depth answer which refers to scientific articles. The information given here is regularly updated with the latest.

Slide 1 Alcohol and Stress Hormones Hilary J. Little Institute of Psychiatry, University of London, United Kingdom Slide 2 Effects of alcohol i) Acute effects ii) Long ter Mifepristone: Asteroidalantiprogestogen, it might be utilized along with Misoprostol for an early pregnancy misfortune. This drug is usually used in a blend with Misoprostol for a fetus removal during pregnancy. This blend is 97% successful during the initial 63 days of pregnancy. It is typically taken by mouth

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International Journal of Molecular Sciences (2021-04-01) . Effect of Glucocorticoid Receptor Antagonism on Alcohol Self-Administration in Genetically-Selected Marchigian Sardinian Alcohol-Preferring and Non-Preferring Wistar Rat Misoprostol is the second abortion pill that is used after taking Mifeprex/Mifepristone. Mifeprex is an anti-progesterone that is taken to stop the working of progesterone. Both the pills are equally necessary to end the pregnancy. So after taking Mifepristone 200 mg you need to wait for 24-48 hours and then take the secondary dosage A = alcohol vehicle; R = 200 μg/mL mifepristone (RU486); M = 200 μg/mL methoprene; and M+R = 200 μg/mL methoprene plus 200 μg/mL mifepristone (RU486). ANOVA is presented below the graph. The p value for significance with 4 comparisons is .05/4 = .0125. (D-F) Metabolite levels. Metabolite levels (log 2 abundance) are presented in box plots. Mifepristone(Mifeprex) generic is a synthetic steroid, used alone or together with another medication, to end an early pregnancy (within 7 weeks of the start of a woman's last menstrual period) Mifepristone Linepharma is an anti-hormone that acts by blocking the effects of progesterone, a hormone which is needed for pregnancy to continue. Mifepristone Linepharma can therefore cause termination of pregnancy. Mifepristone Linepharma is recommended for the medical termination of a pregnancy:.

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A Pilot Study on the Safety and Efficacy of Mifepristone for the Prevention of Relapses of Alcohol Drinking. Home; Study Search; Study Details From Other Databases; Providence, Rhode Island 02912. Alcohol Use Disorders (AUD) Purpose: The goal of this study is to determine if, under stress, alcohol drinking is reduced using mifepristone. Mifepristone (20 or 40 mg/kg) or vehicle (peanut oil) are administered subcutaneously (s.c.) once daily following the 0800 administration of EtOH or control diet. Mifepristone is suspended in peanut oil and sonicated for 30 minutes at least 24 hours prior to injection, it is then stored at 4°C until needed Mifepristone - CAS 84371-65-3 - Calbiochem. Synonyms: Mifepristone - CAS 84371-65-3 - Calbiochem. CAS Number: 84371-65-3. Molecular Weight: 429.59. Empirical Formula (Hill Notation): C 29 H 35 NO 2. Product Number Product Description SDS; 475838: A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and.

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Andrew Marvell Centre for Medieval and Early Modern Studies Archaeology and Landscapes Studies Research Centre / Wetland Archaeology and Environments Research Centre Blaydes Maritime Centre Centre for Applied Research and Evaluation Centre for British Politics Centre for City and Regional Studies Centre for Criminology and Criminal Justice Centre for End of Life Studies Centre for European. For consultation 24 hours a day, 7 days a week with an expert in mifepristone, call Danco Laboratories at 1-877-4 Early Option (1-877-432-7596). 3 DOSAGE FORMS AND STRENGTHS . Tablets containing 200 mg of mifepristone each, supplied as 1 tablet on one blister card 11β-(4-Dimethyl­amino)­phenyl-17β-hydroxy-17-(1-propynyl)­estra-4,9-dien-3-one, RU-486, RU-3848 Mifepristone, the primary medication is an anti-progesterone that competitively inhibits the action of progesterone. The pregnancy-maintaining hormone thus fails to function. This causes a breakdown of the endometrial lining and the implanted blastocyst (that would have progressed to be a fetus) is separated Alcohol 13: Naltrexone 3: Gabapentin 3: Fosaprepitant Dimeglumine 2: Aprepitant 2: Nicotine 2: Mifepristone 2: Naltrexone Hydrochloride 2: Acamprosate Calcium 1: Apremilast 1: Pregabalin 1: Suvorexant 1: Fenofibrate 1: View More: Sponsor Type: Business 1: Hospital 30: Government 2: University 5: Sponsor: The Scripps Research Institute: National.

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Mifepristone is a safe medication and FDA's in-person dispensing requirements provide no medical benefit to patients. There is no basis for FDA's decision to treat mifepristone differently than other medications EUROPEAN PHARMACOPOEIA Free access to supportive pharmacopoeial texts in the field of vaccines for human use during the coronavirus disease (COVID-19 Take mifepristone by mouth as directed by your health care professional, usually as a single dose. Swallow the mifepristone with a glass of water. After taking mifepristone, wait 24 to 48 hours, then take the misoprostol (as a single dose). To take the misoprostol, place the tablets between your cheeks and gums and allow to dissolve for 30 minutes

JCI - Glucocorticoid receptor antagonism decreases alcohol

Mifepristone, as a potent antagonist of glucocorticoid receptors, has been studied or is currently being investigated as a potential therapeutic agent for alcohol and cocaine dependence, psychotic depression, post-traumatic stress disorder, as well as for mitigating the weight gain associated with the use of anti-psychotic drugs and for. Initially by vagina, or by buccal administration, or by sublingual administration. For Adult. 800 micrograms for 1 dose, dose to be given 24-48 hours after mifepristone, if abortion has not occurred 4 hours after first misoprostol dose a further dose may be given, (by mouth or by vagina) 400 micrograms for 1 dose case study-alcohol - Ministry of Health. Drug Abuse. Inpatient treatment and care of people. Workshop 7. withdrawal - University of Kentucky Download Repor

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Swallow the mifepristone pill with a glass of water. Plan to take this pill a full 24-48 hours before you take the misoprostol pills. You likely won't feel any symptoms after taking mifepristone and can go about your normal day freely. If you throw up in the first 30 minutes after taking the pill, it likely won't work and you might have to take it again. Call your doctor to see if you need. If you feel unable to talk to friends or family about your decision, you can speak to a MSI Reproductive Choices counsellor, to your GP, or to a contraception and sexual health clinic. If you don't want to talk to your GP, that's ok too. You can call us any time on 0345 300 8090 to talk through your options Moved Permanently. The document has moved here Buy Cytolog Misoprostol Online. Cytolog or cytotec contains misoprostol, a prostaglandin analog that has been well-studied for its use as an abortifacient. It has been used widely for the induction of an abortion within 10 weeks of gestation in combination with an anti-progestin. An overall complete abortion rate for this medication is well.